Mayor Phlegmming

Mayor Charles Phlegmming (William Shatner) is the grumpy, short, and self-centered mayor of the city of Frank. He is shown throughout the movie campaigning for reelection against Tom Colonic. He is the secondary antagonist of the film.

Personality

Phlemming is corrupt, reckless, irresponsible, and his policies are largely responsible for Frank's deteriorating health.

His rash and incautious nature causes him to be blown away at the end of the movie as he presses a button, reading "DO NOT TOUCH!" which triggers Frank's farting.

Osmosis Jones (film)

Phlemming campaigns for his reelection throughout most of the film. He and his assistant Leah were the first cells to know of an impending threat to Frank. To cover this up, he takes control of Frank and makes him take a cold pill. He also fires Osmosis for blowing up the zit, even though it was the right thing to do.

As Frank almost dies from Thrax's attack, he is presumed to have resigned his position in office. He is last seen as a janitor cleaning a section of the bowels, where he accidentally ejects himself through the rectum. 

Trivia

• It is implied that his rival, Tom Colonic, won the election at the end of the film.
• He is voiced by William Shatner, and his personality is modeled after Richard Nixon.