Drixenol Koldreliff
Drix 300

Other Name:



Bulky robotic body






Osmosis Jones


Thrax, germs and virus


Healing arm cannon

Voiced by:

David Hyde-Pierce (film)
Jeff Bennett (TV series)

Drixenol Koldreliff, or Drix for short, is a a red and yellow, boxy, and robotic cold pill who becomes Ozzy's best friend and Maria's love interest.


Drix is intelligent, clever, and dedicated to work. Straight-laced and by-the-book, he is in disagreement with the crude humor and unorthodox methods of Ozzy, but respects Ozzy as a partner due to his dedication to fighting diseases.

Osmosis Jones (film)Edit

Drix arrives in Frank at request of the Mayor to help cover up the cold symptoms that would hurt his reelection campaign. After gathering information from Chill, he and Ozzy go up to the Zit to confront Thrax and his men.   

There, almost everyone is killed due to one of his medicine grenades being thrown by Osmosis Jones. Both he and Ozzy are fired by the mayor for excessive force, and in an attempt to cover the seriousness of Thrax's infection.   

Just before Drix leaves Frank by way of the Bladder, he teams back up with Ozzy and hunts down Thrax. He and Ozzy chase Thrax from the Hypothalamus to the mouth, where they confront him in the Uvula.   

Thrax triggers a sneeze and rides the shockwave out by expanding his coat. Drix launches Ozzy after him, and they both land on Shane's eye. As the fight goes down, the temperature in Frank hits 108 degrees. Ozzy arrives back at the Uvula in one of Shane's tears with the missing DNA strand. As they are being awarded by the City, Ozzy asks Drix to stay in Frank and continue to help out.   

Ozzy and DrixEdit

Roughly a year after the events of Osmosis Jones, Ozzy and Drix are transferred by a mosquito bite to Hector Cruz. After saving Hector from the Scarlet Fever virus that came with them, Ozzy and Drix decide to stay and prevent Hector from becoming a disgusting degenerate like Frank. Drix's personality is slightly altered from what it was in the film, becoming more neurotic and naive. 


  • Drix, Auntie Histamine, Penicillin G, and Drixine are the only medications to be featured in Ozzy & Drix
  • David Hyde Pierce was hired for the role of Drix because he was "the whitest white man" they could find.
  • Drix had to be shown how to dance by Ozzy.

Gallery Edit

Screenshots and other images can be found at Drix/Gallery.

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